MEMBRANE EVOLUTION CHRONOLOGY

Fresenius Polysulfone®

The first industrially-produced
polysulfone membrane

Helixone®

A new standard set by Nano Controlled
Spinning (NCSTM) technology for highly
defined pore structure

Helixone®plus

Focus on middle molecule removal,
such as β2-microglobulin

1,000,000,000

dialysers produced –
trusted membrane expertise

HELIXONE® hydro

The new membrane that forms a
hydrolayer on the inner membrane
surface for reduced protein
adsorption

Fresenius Polysulfone®

The first industrially-produced
polysulfone membrane

Helixone®

A new standard set by Nano Controlled
Spinning (NCSTM) technology for highly
defined pore structure

Helixone®plus

Focus on middle molecule removal,
such as β2-microglobulin

1,000,000,000

dialysers produced –
trusted membrane expertise

HELIXONE® hydro

The new membrane that forms a
hydrolayer on the inner membrane
surface for reduced protein
adsorption

NINE TYPES FOR INDIVIDUALISED PATIENT PRESCRIPTION

FX CorAL

FX CorAL combines clinical performance with haemocompatibility, because these two factors belong together in Patient Centred Dialysis.

FX CorAL’s Helixone® hydro membrane forms a hydrolayer on the inner membrane surface for reduced protein adsorption, resulting in a membrane with low immune response and high selective permeability.1-4

FX CorAL
Haemodiafilters

The FX CorAL product line includes haemodiafilters specially designed to deliver HighVolumeHDF.

FX CorAL haemodiafilters have an increased inner fibre lumen of 210 μm, facilitating improved blood flow conditions for high convective volume in HDF treatment.

FUNCTIONAL FX PROPERTIES MAKE A DIFFERENCE

LIGHTWEIGHT MATERIAL INLINE STEAM STERILISATION UNIQUE FIBRE ARCHITECTURE AND HOUSING PINNACLE DESIGN LATERAL BLOOD INLET PORT IMPROVED HEADER DESIGN
LIGHTWEIGHT MATERIAL
The housing material of any FX Dialyser is made of environmentally friendly and lightweight polypropylene. Due to the advanced material, FX Dialysers are up to 50% lighter (before treatment) than dialysers made of polycarbonate.8

The reduced weight of an FX Dialyser may improve the end-of-life management by producing up to 1,600 kg less waste9 per year for an average dialysis clinic, also contributing to cost savings.
INLINE STEAM STERILISATION
Each FX Dialyser is individually sterilised by the unique INLINE steam sterilisation method. Both the blood and the dialysate compartments of the dialyser are rinsed continuously with steam at a minimum temperature of 121° C. Rinsing with hot steam assures a gentle sterilisation without the need for chemicals or irradiation, which may lead to increased cytotoxic10 and carcinogenic residuals.11,12

Moreover, cytotoxicity is minimal after steam sterilisation, whereas it increases with gamma irradiation.16 Studies have shown that with steam sterilised dialyser membranes, less oxidative stress is induced to the patient’s blood, compared to gamma sterilisation.13,14,15

In addition, changes of the material properties can be observed after sterilisation with gamma irradiation, while the material remains intact when using steam sterilisation.16 Moreover, the elution of PVP from the dialysis membranes was lowest for dialysers sterilised with INLINE steam and highest for autoclave steam sterilised dialysers.2 Increased losses of albumin during dialysis sessions have been observed with gamma sterilised dialysers which had been stored for a longer time.10,17
UNIQUE FIBRE ARCHITECTURE
AND HOUSING PINNACLE DESIGN
The unique microwave fibre structure enables the homogenous distribution of dialysis fluid, supported by the inner housing’s pinnacle design of all FX Dialysers. This prevents the channelling of the dialysis fluid and ensures that each fibre within the bundle is surrounded by the dialysis fluid, contributing to improved clearances.5,6,7

LATERAL BLOOD
INLET PORT
The characteristic blue FX Dialyser header, with its laterally placed blood inlet port is designed to reduce the risk of kinked bloodlines, aiming at smooth handling.

IMPROVED HEADER DESIGN
The improved header design of FX Dialysers ensures a homogenous blood flow path. Its geometry allows a spiral distribution of blood in the dialyser header, preventing low-velocity stagnation zones and resulting in an enhanced performance.5

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REFERENCES